Vhl Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comVhl Polyclonal Antibody for Rat(Rattus norvegicus)

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Vhl (Gene name),

Von Hippel-Lindau disease tumor suppressor (Protein name ), VHL_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Vhl;

Protein name:

Von Hippel-Lindau disease tumor suppressor;

Alternative:

pVHL;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Part of a complex with Elongin BC complex and hydroxylated HIF1A. Interacts with CUL2. Part of multisubunit CBC(VHL) E3 ubiquitin ligase complexes with Elongin BC complex, CUL2 or CUL5 and RBX1. Interacts with HIF1AN. Part of a complex with HIF1A, HIF1AN and HDAC1 or HDAC2 or HDAC3. The C-terminus interacts with VBP1. Interacts with RNF139 and USP33. Interacts with PHF17.

Function:

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Nucleus

Protein Attributes:

Sequence length:

185

Sequence:

50:

100:

150:

185:

YEDLEDHPNV | RKDIQRLTQE | HLENQALGEE | PEGVH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01847

SMR:

Q64259

STRING:

10116.ENSRNOP00000013727

UniGene:

Rn.11059

String:

Q64259

KEGG:

rno:24874

Uniprot:

Q64259

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ELISA Kit for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

E1894h

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96T

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ELISA Kit for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

E1894r

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96T

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ELISA Kit for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

E1894m

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MSDS:

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Packing:

96T

ELISA Kit for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

E1894d

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Packing:

96T

CLIA Kit for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

U1894d

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Packing:

96T

CLIA Kit for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

U1894h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

U1894m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

U1894r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

P1894Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

P1894Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Von Hippel-Lindau disease tumor suppressor

Cat.:

P1894Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Von Hippel-Lindau disease tumor suppressor

Protein for Rat Von Hippel-Lindau disease tumor suppressor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations."
Duan D.R. , Humphrey J.S. , Chen D.Y. , Weng Y. , Sukegawa J. , Lee S. , Gnarra J.R. , Linehan W.M. , Klausner R.D.
Proc. Natl. Acad. Sci. U.S.A.92:6459-6463(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas."
Kikuchi Y. , Kobayashi E. , Nishizawa M. , Hamazaki S. , Okada S. , Hino O.
Jpn. J. Cancer Res.86:905-909(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus."
Walker C. , Ahn Y.T. , Everitt J. , Yuan X.
Mol. Carcinog.15:154-161(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-153
4.

"pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2."
Yang H. , Minamishima Y.A. , Yan Q. , Schlisio S. , Ebert B.L. , Zhang X. , Zhang L. , Kim W.Y. , Olumi A.F. , Kaelin W.G. Jr.
Mol. Cell28:15-27(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARD9

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